TABLE 1.
Tissue | Finding(s) | Score with w/o/w emulsion control | Score with TDM dose of:
|
Score with SL dose of:
|
||||
---|---|---|---|---|---|---|---|---|
3 mg | 10 mg | 20 mg | 3 mg | 10 mg | 20 mg | |||
Lung | Granulomas | + | ++ | ++ | +++ | ± | − | − |
Mature and immature macrophages | ± | ++ | ++ | +++ | − | + | + | |
Epithelioid cells | − | + | +++ | +++ | − | − | − | |
Lymphocytes | − | + | + | + | − | − | − | |
Multinucleated giant cells | − | ± | + | + | − | − | − | |
Focal pneumonia and/or perivasculitis | + | + | + | + | + | + | + | |
Liver | Granulomas, interlobular | ± | ± | + | + | − | − | ± |
Epithelioid cells | − | + | ++ | ++ | − | − | − | |
Lymphocytes | − | + | + | + | − | − | − | |
Multinucleated giant cells | − | ± | ++ | ++ | − | − | − | |
Granulomas, portal tract | ± | + | + | + | − | − | − | |
Necrosis, hepatocytes, focal | − | − | + | ++ | − | − | − | |
Spleen | Apoptosis, white pulp | − | − | + | + | − | − | − |
Granulomas, white pulp | + | ± | ± | + | − | + | + | |
Follicular hyperplasia | − | + | + | + | − | − | − | |
Splenitis | − | + | + | + | + | + | + | |
Thymus | Apoptosis, cortex | − | − | + | + | − | − | − |
Grade: ±, very slight; +, slight; ++, moderate; +++, marked; −, not detected.