TABLE 1.
Histopathological findings in New Zealand White rabbits given a single intravenous administration of glycolipids from M. tuberculosis AOYAMA-Ba
| Tissue | Finding(s) | Score with w/o/w emulsion control | Score with TDM dose of:
|
Score with SL dose of:
|
||||
|---|---|---|---|---|---|---|---|---|
| 3 mg | 10 mg | 20 mg | 3 mg | 10 mg | 20 mg | |||
| Lung | Granulomas | + | ++ | ++ | +++ | ± | − | − |
| Mature and immature macrophages | ± | ++ | ++ | +++ | − | + | + | |
| Epithelioid cells | − | + | +++ | +++ | − | − | − | |
| Lymphocytes | − | + | + | + | − | − | − | |
| Multinucleated giant cells | − | ± | + | + | − | − | − | |
| Focal pneumonia and/or perivasculitis | + | + | + | + | + | + | + | |
| Liver | Granulomas, interlobular | ± | ± | + | + | − | − | ± |
| Epithelioid cells | − | + | ++ | ++ | − | − | − | |
| Lymphocytes | − | + | + | + | − | − | − | |
| Multinucleated giant cells | − | ± | ++ | ++ | − | − | − | |
| Granulomas, portal tract | ± | + | + | + | − | − | − | |
| Necrosis, hepatocytes, focal | − | − | + | ++ | − | − | − | |
| Spleen | Apoptosis, white pulp | − | − | + | + | − | − | − |
| Granulomas, white pulp | + | ± | ± | + | − | + | + | |
| Follicular hyperplasia | − | + | + | + | − | − | − | |
| Splenitis | − | + | + | + | + | + | + | |
| Thymus | Apoptosis, cortex | − | − | + | + | − | − | − |
a
Grade: ±, very slight; +, slight; ++, moderate; +++, marked; −, not detected.