Table 2.
Univariate and Multivariate Logistic Regression Analysis to Identify Risk Factors
| Univariate | P-value | Multivariate | P-value | |
|---|---|---|---|---|
| OR (95% CI) | OR (95% CI) | |||
| Voriconazole trough concentration, mg/L | 1.25 (1.09–1.42) | 0.001 | 1.28 (1.11–1.46) | 0.001 |
| Age, years | n.s | 0.708 | 1.02 (0.99–1.05) | 0.254 |
| Weight, kg | n.s | 0.807 | - | |
| Gender, female (male) | 0.51 (0.18–1.43) | 0.202 | - | |
| Concomitant use of neurotoxic drugs | ||||
| Overall | 0.51 (0.14–1.81) | 0.296 | 0.41 (1.00–1.79) | 0.236 |
| Fluoroquinolone | 0.62 (0.27–1.42) | 0.258 | - | |
| Cephalosporins | 0.97 (0.3–3.14) | 0.96 | - | |
| Carbapenems | 0.78 (0.36–1.65) | 0.508 | - | |
| Linezolid | 0.69 (0.28–1.72) | 0.429 | - | |
| Others | 1.59 (0.75–3.41) | 0.229 | - | |
| ALT(U/L) | n.s | 0.221 | n.s | 0.074 |
| AST(U/L) | n.s | 0.177 | - | |
| ALP(U/L) | n.s | 0.467 | - | |
| TBIL (mol/L) | n.s | 0.592 | - | |
| DBIL (mol/L) | n.s | 0.136 | - | |
| ALB(g/L) | 1.02 (0.97–1.08) | 0.444 | - |
Abbreviations: OR, odds ratio; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; TBIL, total bilirubin; DBIL, direct bilirubin; ALB, albumin; n.s, not significant at the 5% concentration.