. 2022 Dec 16;18:2927–2943. doi: 10.2147/NDT.S273503

Table 2.

Conventional Psychotropic Pharmacotherapy Studies for the Treatment of TRBD

Author, Year	Study Design	Intervention	Sample Size (n)	Outcome measure	Key Outcome
Nierenberg et al, 2006¹¹	3-arm RCT	Lamotrigine	66	Rate of recovery	No significant difference between groups.
		Inositol			Post-hoc analysis suggest lamotrigine may be superior.
		Risperidone			Post-hoc analysis suggest lamotrigine may be superior.
Goldberg et al, 2004³²	RCT	Placebo	22	Response (HDRS improvement >50%)	67% of pramipexole responded vs 20% of placebo group.
Goldberg et al, 2004³²	RCT	Pramipexole (flexible dose)	22	CGI	Mean improvement in HDRS and CGI better in pramipexole group.
Frye et al, 2007³⁵	RCT	Modafinil 177 mg/d	85	IDS	Significantly greater IDS change in treatment group compared with placebo.
Frye et al, 2007³⁵	RCT	Placebo	85	Response/remission	Response and remission were significant.
Murphy et al, 2014³³	RCT	Naltrexone 50 mg/d	30	MADRS	No significant difference.
Murphy et al, 2014³³	RCT	Placebo	30	HDRS	No significant difference.