Table 2. Burden analysis results showing statistically significant difference when comparing the number of rare functional variants in the proband group to the control group for HIF1A, VHL, and IDH1.
| Group | Proband samples | Control samples | p (FET) | OR (95% CI) |
|---|---|---|---|---|
| With HIF1A variants | 7 | 37 | 0.002 | 4.3 (1.9 to 10.1) |
| Without HIF1A variants | 87 | 2017 | ||
| With VHL variants | 6 | 8 | 1.36e-05 | 17.4 (5.9 to 51.3) |
| Without VHL variants | 88 | 2046 | ||
| With IDH1 variants | 3 | 11 | 0.02 | 6.1 (1.6 to 22.3) |
| Without IDH1 variants | 91 | 2043 |