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. 2022 Dec 20;17(12):e0276115. doi: 10.1371/journal.pone.0276115

Fig 4. Single-cell RNA sequencing displays the proportion of three different cell types and SARS-CoV-2 host factors present in uninfected human alveolar-like organoids.

Fig 4

UMAP embedding of human alveolar-like organoids (n = 6; P1-P3 and P10-P12) shows AT2, basal, and secretory cells present in the organoids (A). Cell cycle phase of each cell in either G2M, S or G1 phase (B) and individual donor composition (C) is displayed. The marker genes needed for cell type identification are shown (D and E) as well as the expression of the SARS-CoV-2 host factors ACE2, TMPRSS2, and FURIN (F).