Fig 2. Visualization of different outcomes of oncolytic virotherapy.

In our model, virus infection in the tumour tissue can result in four therapeutic outcomes: (A) total cancer eradication; (B) partial cancer eradication; (C) persistence of a virus-sensitive cancer; and (D) persistence of a partially virus-resistant cancer. The snapshot (t = 60) indicates the parameter values in regard to which the four simulations differ from each other: the rate of viral spread (b_i), the death rate of infected cells (d_i), and the probability that the daughter cell of a sensitive cancer cell becomes resistant (Cr).