Appendix 1—table 1. Association of age, sex, and white blood cell (WBC) parameters with mitochondrial DNA copy number (mtDNAcn).
| β (p-value) of model adjusted | ||||
|---|---|---|---|---|
| No adjustment | Age, sex, coverage, and WBC parameters | |||
| Trait | BLSA | SardiNIA | BLSA | SardiNIA |
| Age | –0.025 (2.85e-13) | –0.0093 (0.003) | –0.014 (2.52e-5) | –0.0065 (0.028) |
| Sex | –0.61 (8.14e-17) | –0.25 (0.004) | –0.36 (1.21e-6) | –0.13 (0.11) |
| Platelet count | 0.004 (1.31e-7) | 0.0007 (0.30) | 0.003 (3.71e-6) | 0.001 (0.063) |
| WBC count | –0.13 (2.35e-10) | –0.14 (1.37e-8) | –0.097 (1.48e-6) | –0.08 (0.002) |
| Lymphocytes percent | 0.04 (5.5e-25) | 0.042 (5.19e-16) | –0.033 (0.23) | 0.073 (0.55) |
| Neutrophils percent | –0.041 (1.47e-28) | –0.041 (6.19e-18) | –0.063 (0.021) | 0.036 (0.77) |
| Eosinophils percent | 0.037 (0.031) | 0.043 (0.06) | –0.045 (0.16) | 0.076 (0.55) |
| Monocytes percent | 0.022 (0.082) | 0.062 (0.002) | –0.014 (0.57) | 0.082 (0.52) |
| Basophils percent | 0.44 (8.54e-5) | 0.11 (0.38) | 0.044 (0.69) | –0.076 (0.55) |
BLSA, Baltimore Longitudinal Study of Aging.