Appendix 1—table 2. Association of Revised NEO Personality Inventory (NEO-PI-R) domains with mitochondrial DNA copy number (mtDNAcn).
| NEO-PI-R domains | BLSA β (p-value) | SardiNIA β (p-value) | Meta-analysis | |||
|---|---|---|---|---|---|---|
| Pooled β | Raw p-value | FDR adj. p* | I2 % [p of Q] | |||
| Neuroticism | –0.106 (0.001) | –0.116 (0.01) | –0.11 | 0.00006 | 0.0015 | 0% [0.87] |
| Anxiety | –0.082 (0.01) | –0.086 (0.08) | –0.08 | 0.002 | 0.010 | 0% [0.94] |
| Angry hostility | –0.078 (0.02) | –0.090 (0.054) | –0.08 | 0.003 | 0.010 | 0% [0.84] |
| Depression | –0.122 (0.0002) | –0.070 (0.1) | –0.11 | 0.00008 | 0.0015 | 0% [0.37] |
| Self-consciousness | –0.060 (0.08) | –0.116 (0.01) | –0.08 | 0.004 | 0.013 | 0% [0.33] |
| Impulsiveness | –0.067 (0.046) | –0.023 (0.6) | –0.05 | 0.06 | 0.099 | 0% [0.45] |
| Vulnerability | –0.080 (0.02) | –0.097 (0.04) | –0.09 | 0.002 | 0.0087 | 0% [0.77] |
| Extraversion | 0.083 (0.01) | 0.117 (0.01) | 0.09 | 0.0005 | 0.0036 | 0% [0.56] |
| Warmth | 0.064 (0.06) | 0.162 (0.0004) | 0.11 | 0.03 | 0.051 | 66% [0.09] |
| Gregariousness | 0.040 (0.2) | 0.047 (0.3) | 0.04 | 0.1 | 0.16 | 0% [0.90] |
| Assertiveness | 0.066 (0.048) | –0.007 (0.9) | 0.04 | 0.3 | 0.36 | 38% [0.21] |
| Activity | 0.106 (0.002) | 0.037 (0.4) | 0.08 | 0.02 | 0.040 | 30% [0.23] |
| Excitement seeking | 0.011 (0.7) | 0.067 (0.2) | 0.03 | 0.3 | 0.36 | 0% [0.35] |
| Positive emotions | 0.087 (0.01) | 0.122 (0.01) | 0.10 | 0.0004 | 0.0036 | 0% [0.54] |
| Openness | 0.066 (0.06) | 0.076 (0.1) | 0.07 | 0.01 | 0.032 | 0% [0.86] |
| Fantasy | –0.006 (0.9) | 0.093 (0.051) | 0.04 | 0.4 | 0.48 | 65% [0.09] |
| Aesthetics | 0.015 (0.7) | 0.086 (0.06) | 0.04 | 0.2 | 0.27 | 34% [0.22] |
| Feelings | 0.045 (0.2) | –0.015 (0.8) | 0.02 | 0.4 | 0.47 | 2% [0.31] |
| Actions | 0.063 (0.07) | 0.039 (0.4) | 0.05 | 0.051 | 0.094 | 0% [0.68] |
| Ideas | 0.079 (0.02) | 0.070 (0.1) | 0.08 | 0.005 | 0.014 | 0% [0.88] |
| Values | 0.078 (0.02) | –0.014 (0.8) | 0.04 | 0.4 | 0.46 | 59% [0.12] |
| Agreeableness | 0.058 (0.1) | 0.141 (0.003) | 0.09 | 0.02 | 0.047 | 49% [0.16] |
| Trust | 0.085 (0.014) | 0.065 (0.2) | 0.08 | 0.005 | 0.014 | 0% [0.73] |
| Straightforwardness | 0.059 (0.08) | 0.095 (0.04) | 0.07 | 0.009 | 0.024 | 0% [0.54] |
| Altruism | 0.077 (0.02) | 0.133 (0.005) | 0.10 | 0.0005 | 0.0036 | 0% [0.34] |
| Compliance | 0.005 (0.9) | 0.039 (0.4) | 0.02 | 0.5 | 0.57 | 0% [0.57] |
| Modesty | –0.018 (0.6) | 0.080 (0.09) | 0.03 | 0.6 | 0.62 | 65% [0.09] |
| Tendermindedness | 0.030 (0.4) | 0.089 (0.053) | 0.05 | 0.07 | 0.12 | 7% [0.30] |
| Conscientiousness | 0.084 (0.009) | 0.040 (0.4) | 0.07 | 0.008 | 0.022 | 0% [0.43] |
| Competence | 0.115 (0.0004) | 0.024 (0.6) | 0.08 | 0.09 | 0.14 | 61% [0.11] |
| Order | –0.003 (0.9) | 0.036 (0.4) | 0.01 | 0.7 | 0.69 | 0% [0.49] |
| Dutifulness | 0.097 (0.003) | 0.066 (0.2) | 0.09 | 0.001 | 0.0064 | 0% [0.57] |
| Achievement striving | 0.093 (0.005) | 0.018 (0.7) | 0.06 | 0.09 | 0.14 | 42% [0.19] |
| Self-discipline | 0.056 (0.08) | 0.016 (0.7) | 0.04 | 0.1 | 0.14 | 0% [0.48] |
| Deliberation | 0.069 (0.03) | 0.009 (0.8) | 0.05 | 0.09 | 0.14 | 11% [0.29] |
| Personality and mortality | BLSA Md (p-value) | SardiNIA Md (p-value) | Pooled Md | Raw p-value | FDR adj. p | I2 % [p of Q] |
| HVLD vs. LVHD | 0.234 (0.006) | 0.209 (0.09) | 0.226 | 0.0013 | - | 0% [0.87] |
BLSA, Baltimore Longitudinal Study of Aging; HVLD, high vulnerability low self-discipline; LVHD, low vulnerability high self-discipline; FDR, false discovery rate.
*
Entries with FDR-corrected p-values≤0.01 are labeled as bold.