Appendix 1—table 5. Association of Revised NEO Personality Inventory (NEO-PI-R) domains with mitochondrial DNA copy number (mtDNAcn) in SardiNIA women, with and without adjustment for menopause status.

Both models adjusted for the effect of age, sequence coverage, white blood cell (WBC), platelet count, and percentages of major leukocytes.

	β (p-value) of model
NEO-PI-R domains	Not adjusted for menopause status	Adjusted for menopause status
Neuroticism	–0.013 (0.074)	–0.013 (0.077)
Anxiety	–0.007 (0.316)	–0.007 (0.323)
Angry hostility	–0.010 (0.123)	–0.010 (0.127)
Depression	–0.008 (0.236)	–0.008 (0.240)
Self-consciousness	–0.012 (0.056)	–0.012 (0.056)
Impulsiveness	0.002 (0.794)	0.002 (0.802)
Vulnerability	–0.011 (0.059)	–0.011 (0.063)
Extraversion	0.017 (0.022)	0.017 (0.021)
Warmth	0.021 (0.0004)	0.021 (0.0004)
Gregariousness	0.005 (0.483)	0.005 (0.476)
Assertiveness	0.002 (0.828)	0.001 (0.862)
Activity	0.001 (0.857)	0.001 (0.864)
Excitement seeking	0.010 (0.183)	0.010 (0.165)
Positive emotions	0.014 (0.020)	0.015 (0.017)
Openness	0.014 (0.035)	0.014 (0.036)
Fantasy	0.017 (0.016)	0.017 (0.016)
Aesthetics	0.011 (0.098)	0.011 (0.102)
Feelings	0.007 (0.319)	0.007 (0.312)
Actions	0.008 (0.195)	0.008 (0.192)
Ideas	0.009 (0.189)	0.009 (0.186)
Values	0.001 (0.887)	0.001 (0.910)
Agreeableness	0.017 (0.010)	0.017 (0.011)
Trust	0.006 (0.313)	0.006 (0.321)
Straightforwardness	0.012 (0.050)	0.012 (0.055)
Altruism	0.012 (0.042)	0.012 (0.041)
Compliance	0.008 (0.175)	0.008 (0.179)
Modesty	0.005 (0.471)	0.005 (0.499)
Tendermindedness	0.013 (0.025)	0.013 (0.024)
Conscientiousness	0.006 (0.409)	0.005 (0.428)
Competence	0.001 (0.846)	0.001 (0.857)
Order	0.003 (0.606)	0.003 (0.637)
Dutifulness	0.006 (0.325)	0.006 (0.346)
Achievement striving	0.005 (0.471)	0.005 (0.442)
Self-discipline	0.001 (0.854)	0.001 (0.908)
Deliberation	0.005 (0.414)	0.005 (0.417)