Table 2. Association of Neuroticism domain with mitochondrial DNA copy number (mtDNAcn).
| Domain and facets | BLSA β (p-value) | SardiNIA β (p-value) | Pooled β (p-value)* | I2 % [p of Q] |
|---|---|---|---|---|
| Neuroticism | –0.106 (0.001) | –0.116 (0.01) | –0.11 (0.0015) | 0% [0.87] |
| Anxiety | –0.082 (0.01) | –0.086 (0.08) | –0.08 (0.010) | 0% [0.94] |
| Angry hostility | –0.078 (0.02) | –0.090 (0.054) | –0.08 (0.010) | 0% [0.84] |
| Depression | –0.122 (0.0002) | –0.070 (0.1) | –0.11 (0.0015) | 0% [0.37] |
| Self-consciousness | –0.060 (0.08) | –0.116 (0.01) | –0.08 (0.013) | 0% [0.33] |
| Impulsiveness | –0.067 (0.046) | –0.023 (0.6) | –0.05 (0.099) | 0% [0.45] |
| Vulnerability | –0.080 (0.02) | –0.097 (0.04) | –0.09 (0.0087) | 0% [0.77] |
| Measures of depressive symptoms | ||||
| CES-D continuous | –0.122 (0.0002) | –0.077 (0.13) | –0.11 (0.00008) | 0% [0.46] |
| CES-D binary cutoff 16 | –0.260 (0.051) | –0.180 (0.13) | –0.22 (0.015) | 0% [0.65] |
| CES-D binary cutoff 20 | –0.591 (0.005) | –0.343 (0.02) | –0.42 (0.0004) | 0% [0.34] |
| PMI | ||||
| Personality-mortality index | 0.092 (0.005) | 0.124 (0.007) | 0.10 (0.0001) | 0% [0.57] |
BLSA, Baltimore Longitudinal Study of Aging; CES-D, Center for Epidemiologic Studies Depression Scale; PMI, personality-mortality index; FDR, false discovery rate.
*
Pooled effect p-values of Neuroticism domain and facets are FDR-corrected for 35 tests for 35 personality traits. Information for other personality domains and facets are provided in Appendix 1—table 2.