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. 2022 Dec 19;220(3):e20220809. doi: 10.1084/jem.20220809

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© 2022 Shamseddine et al.

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Figure S2. — Characteristics of DNA damage and STING recruited leukocyte population in the heart. (A) Expression of ISGs is especially associated with cells in cluster 12, the IFNIC monocytes and macrophages, with expression of each cell overlaid on the UMAP projections. (B) Extending from Fig. 4 D, with data from each additional cluster identified in UMAP. Plotting the percentage of each cluster of the total cell population of CD45⁺ cells in Sting^+/+ 28 d after sham treatment, Sting^+/+ mice 28 d after cardiac RT, and Sting^gt/gt mice 28 d after cardiac RT. In addition to IFNIC monocytes and macrophages, we also observed increased STING-dependent recruitment of B cells (clusters 6) and dendritic cells (cluster 8) 1 mo after DNA damage. Data in each biologic condition represent two independent scRNA-seq libraries, each composed of CD45⁺ cells isolated from four mice.