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. 2022 Dec 20;3(12):1534–1552. doi: 10.1038/s43018-022-00475-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, An overview of genomics studies on paired longitudinal GBM specimens. b, A t-distributed stochastic neighbor embedding (t-SNE) of the first ten principal components of snRNA-seq data. Cells with CNVs are annotated. n = 86 tumors were used (b–d). c, A hierarchical clustering of cells without CNVs, with several cluster-specific genes highlighted. d, A summary of sample cellular composition, genotype and demographics. Top: cellular composition inferred from snRNA-seq. Middle: patient and sample annotations, with genotype inferred from snRNA-seq. Bottom: genotypes inferred from the UCSF500 clinical DNA-amplicon-sequencing assay performed on adjacent tissue and controlled by sequencing a patient-matched blood specimen.