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. 2022 Dec 20;3(12):1534–1552. doi: 10.1038/s43018-022-00475-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — a) A PCA of GBM neoplastic cells from snRNA-seq with patient age annotated, N = 78,415 cells. b) Annotation of adult vs. adolescent and young-adult status, N = 78,415 cells. c) A comparison of patient age between snRNA-seq neoplastic cells classified as PN vs. MES, N = 72 tumors. *- one-sided Wilcoxon rank-sum test p = 0.0161. Boxplots in panels C and E-F are defined as follows, lower/upper whiskers: smallest/largest observation ≥/≤ the lower/upper hinge −/+ 1.5 times the interquartile range (IQR); lower/upper hinge: 25^th/75^th percentile; center: 50^th percentile. d) A PCA of GBM neoplastic cells from snRNA-seq with location of resection annotated. The distributions along principal component one of cells by location are shown as boxplots below, N = 78,415 cells. e) As above, but with sex annotated, N = 72 tumors. f) A comparison of patient ages between the male and female sex, N = 72 tumors. *- one-sided Wilcoxon rank-sum test p = 0.0389. g) CNV calls from exome-seq for select specimens.