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. 2022 Dec 20;3(12):1534–1552. doi: 10.1038/s43018-022-00475-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — a–c) RNAscope on sections adjacent to Fig. 7a. Alongside are images where cells have been segmented and receptor/ligand stains quantified. Receptor mRNA is tagged red and ligand mRNA is teal. In processed images, ligand-expressing cells are yellow, receptor-positive cells are cyan, double-positive cells are purple, and double-negative cells are red. a) RNA-scope analysis of PTN/PTPRZ1. Double-positive cells are enriched in the cellular tumor, for example region a), PTN-expressing non-malignant cells are more frequent in tumor-adjacent tissue, that is b, c), and this gradient anticorrelates with PTPRZ1-expressing neoplastic cells. b) Gradients of WNT3A and LRP6 expression indicate the presence of both paracrine and autocrine signaling. c) Breakouts of sub-panels x-z) from panel B). d) A breakout of an interface between tumor and non-malignant tissue.