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. 2022 Dec 20;13(12):1059. doi: 10.1038/s41419-022-05505-1

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Under the signal of necroptosis, Brd4 is recruited to the promoter of MLKL and forms a transcription complex with IRF1, P-TEFb, and RNA polymerase II to regulate the expression of MLKL, which leads to necroptosis. BET inhibitors such as JQ1 interferes with the transcription complex formation.