Table 2.
IVW multivariable MR for the effects of T2DM on COVID-19 risk adjusted for BMI.
| Exposure traits | Adjustment | Outcome traits | |||||
|---|---|---|---|---|---|---|---|
| COVID-19 susceptibility | COVID-19 hospitalization | COVID-19 severity | |||||
| Number of SNVs |
OR (95% CI) P-value |
Number of SNVs |
OR (95% CI) P-value |
Number of SNVs |
OR (95% CI) P-value |
||
| Type 2 diabetes | BMI | 150 | 1.14 (1.04–1.25) 0.007 |
149 | 1.20 (1.08–1.35) 0.001 |
136 | 1.28 (1.03–1.59) 0.027 |
The IVW multivariable MR method showed that the BMI-adjusted OR of COVID-19 susceptibility, hospitalization, and severity per log (OR) increase in T2DM were 1.14 (95% CI, 1.04–1.25), 1.15 (1.08–1.35), and 1.28 (1.03–1.59), respectively. BMI, body mass index; CI, confidence interval; COVID-19, coronavirus disease 2019; IVW, inverse variance weighted; MR, Mendelian randomization; OR, odds ratio; SE, standard error; SNVs, single nucleotide variants; T2DM, type 2 diabetes mellitus.