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. 2022 Dec 7;13:1086662. doi: 10.3389/fphar.2022.1086662

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Copyright © 2022 Wei, Wang, Lin, Jin, Li, Wazir, Pu, Lian, Lu, Song, Zhao, Li and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Creatine prevents the browning of white adipose tissue, thereby protecting against adipose tissue wasting. (A) Representative general images and homologous groin images of the three groups. NC group: normal control mice, cachexia group: C26 tumor-bearing mice, cachexia + Cr group: Creatine-treated C26 tumor-bearing mice. (B) iWAT mass changes in the three groups (mean ± SD, n = 6). **p < 0.01 denoted the NC group versus the cachexia group, **p < 0.01 denoted the cachexia group versus the cachexia + Cr group. (C) Representative HE staining showing the morphological changes in the adipose tissue of the three groups. Average size of adipose tissue cross-sectional area in the three groups. (D) Western blot analysis was used to evaluate UCP-1 expression in the three groups (mean ± SD, n = 6). *p < 0.05, **p < 0.01, ***p < 0.001. Data are expressed as the mean ± SD.