Table 2.
Total cohort | 96 patients |
---|---|
Sex M/F | 57 (70%)/39 (30%) |
Age at transplant | 56 years (17–73) |
Cytogenetic risk (28) Favorable Intermediate Adverse |
4 (4%) 79 (82%) 13 (14%) |
ELN risk (7) Favorable Intermediate Adverse |
15 (16%) 43 (45%) 38 (39%) |
Line of treatment before HSCT n.
None 1 2 3 |
4 (4%) 69 (72%) 19 (20%) 4 (4%) |
Median time to transplant | 183.5 days (30 to 645) |
HCT-CI
0 1 2 3 4 ≥5 |
9 (9%) 11 (11%) 17 (18%) 18 (19%) 23 (24%) 18 (19%) |
Year of transplant
2016–2018 2019–2021 |
29 (30%) 67 (70%) |
Disease status at transplant
Never treated CR1 CR2 PR Relapse/refractory |
6 (6%) 54 (56%) 12 (13%) 6 (6%) 18 (19%) |
Conditioning
ABL RIC/NMA |
42 (44%) 54 (56%) |
Donor
HLA Id Sibling Haploidentical Mismatched unrelated Matched unrelated |
21 (22%) 32 (33%) 15 (16%) 28 (29%) |
Stem cell source
PB CB BM |
67 (70%) 4 (4%) 25 (26%) |
GvHD prophylaxis
CSA+Cy CSA+MFA+Cy CSA+MFA CSA+MTX |
4 (4%) 70 (73%) 2 (2%) 20 (21%) |
ATG | 18 (19%) |
M, male; F, female; HCT-CI, hematopoietic cell transplant comorbidity index; CR, complete remission; PR, partial response; ABL, myeloablative; RIC, reduced intensity conditioning; NMA, non-myeloablative conditioning; PB, peripheral blood; CB, cord blood; BM, bone marrow; CSA, cyclosporine A; MFA, micofenolic acid; MTX, methotrexate; CY, cyclophosphamide post-transplant; ATG, anti-thymocyte globulins.