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. 2022 Dec 7;13:997023. doi: 10.3389/fendo.2022.997023

Table 3.

Association between insulin-like growth factor-1 and interventricular septal thickening in various subgroups.

Variables Case/Number Continuous, IGF–I P-value P for interaction Categorical, T3 vs T1–2 P-value P for interaction
OR (95% CI)* OR (95% CI)*
Age
 18–44 years 21/105 1.006 (1.002–1.012) 0.010 3.775 (1.298–12.842) 0.021
 45–59 years 71/323 1.003 (1.002–1.005) <0.001 1.706 (0.970–3.011) 0.064
 ≥60 years 88/698 1.003 (1.001–1.005) 0.013 0.221 1.847 (1.035–3.252) 0.035 0.708
Sex
 Male 116/479 1.003 (1.001–1.005) <0.001 1.454 (0.925–2.280) 0.103
 Female 64/324 1.003 (1.002–1.005) <0.001 0.695 2.834 (1.545–5.229) <0.001 0.099
Hypertension
 No 40/174 1.004 (1.002–1.007) <0.001 1.596 (0.737–3.441) 0.231
 Yes 140/629 1.003 (1.001–1.004) <0.001 0.181 1.896 (1.258–2.852) 0.002 0.770
DM
 No 92/410 1.003 (1.002–1.005) <0.001 1.835 (1.114–3.019) 0.017
 Yes 88/393 1.003 (1.001–1.005) <0.001 0.978 1.835 (1.084–3.095) 0.023 0.981
BMI
 <28 101/499 1.004(1.002–1.006) <0.001 1.567 (0.959–2.545) 0.07
 ≥28 79/304 1.002(1.001–1.004) 0.004 0.220 2.223 (1.293–3.843) 0.004 0.579
Acromegaly
 No 156/763 1.003 (1.001–1.005) 0.002 1.484 (0.997–2.197) 0.05
 Yes 24/40 1.000 (0.997–1.003) 0.872 0.047 0.985 0.981
CAD
 No 134/638 1.003 (1.002–1.004) <0.001 1.635 (1.083–2.465) 0.019
 Yes 46/165 1.005 (1.001–1.010) 0.036 0.374 2.732 (1.265–5.942) 0.01 0.192
SBP (mmHg)
 <140 78/398 1.004 (1.002–1.006) <0.001 1.817 (1.038–3.160) 0.035
 ≥140 102/405 1.002 (1.001–1.004) 0.004 0.471 1.867 (1.158–3.013) 0.01 0.333
DBP (mmHg)
 <90 116/534 1.004 (1.002–1.005) <0.001 1.675 (1.057–2.641) 0.027
 ≥90 64/269 1.003 (1.001–1.005) 0.003 0.343 2.317 (1.255–4.340) 0.008 0.155

BMI, body mass index; CAD, coronary artery disease; DM, diabetes mellitus; SBP, systolic blood pressure; DBP, diastolic blood pressure.

*

Adjusted for propensity scores.