Table 3.
Association between insulin-like growth factor-1 and interventricular septal thickening in various subgroups.
Variables | Case/Number | Continuous, IGF–I | P-value | P for interaction | Categorical, T3 vs T1–2 | P-value | P for interaction |
---|---|---|---|---|---|---|---|
OR (95% CI)* | OR (95% CI)* | ||||||
Age | |||||||
18–44 years | 21/105 | 1.006 (1.002–1.012) | 0.010 | 3.775 (1.298–12.842) | 0.021 | ||
45–59 years | 71/323 | 1.003 (1.002–1.005) | <0.001 | 1.706 (0.970–3.011) | 0.064 | ||
≥60 years | 88/698 | 1.003 (1.001–1.005) | 0.013 | 0.221 | 1.847 (1.035–3.252) | 0.035 | 0.708 |
Sex | |||||||
Male | 116/479 | 1.003 (1.001–1.005) | <0.001 | 1.454 (0.925–2.280) | 0.103 | ||
Female | 64/324 | 1.003 (1.002–1.005) | <0.001 | 0.695 | 2.834 (1.545–5.229) | <0.001 | 0.099 |
Hypertension | |||||||
No | 40/174 | 1.004 (1.002–1.007) | <0.001 | 1.596 (0.737–3.441) | 0.231 | ||
Yes | 140/629 | 1.003 (1.001–1.004) | <0.001 | 0.181 | 1.896 (1.258–2.852) | 0.002 | 0.770 |
DM | |||||||
No | 92/410 | 1.003 (1.002–1.005) | <0.001 | 1.835 (1.114–3.019) | 0.017 | ||
Yes | 88/393 | 1.003 (1.001–1.005) | <0.001 | 0.978 | 1.835 (1.084–3.095) | 0.023 | 0.981 |
BMI | |||||||
<28 | 101/499 | 1.004(1.002–1.006) | <0.001 | 1.567 (0.959–2.545) | 0.07 | ||
≥28 | 79/304 | 1.002(1.001–1.004) | 0.004 | 0.220 | 2.223 (1.293–3.843) | 0.004 | 0.579 |
Acromegaly | |||||||
No | 156/763 | 1.003 (1.001–1.005) | 0.002 | 1.484 (0.997–2.197) | 0.05 | ||
Yes | 24/40 | 1.000 (0.997–1.003) | 0.872 | 0.047 | – | 0.985 | 0.981 |
CAD | |||||||
No | 134/638 | 1.003 (1.002–1.004) | <0.001 | 1.635 (1.083–2.465) | 0.019 | ||
Yes | 46/165 | 1.005 (1.001–1.010) | 0.036 | 0.374 | 2.732 (1.265–5.942) | 0.01 | 0.192 |
SBP (mmHg) | |||||||
<140 | 78/398 | 1.004 (1.002–1.006) | <0.001 | 1.817 (1.038–3.160) | 0.035 | ||
≥140 | 102/405 | 1.002 (1.001–1.004) | 0.004 | 0.471 | 1.867 (1.158–3.013) | 0.01 | 0.333 |
DBP (mmHg) | |||||||
<90 | 116/534 | 1.004 (1.002–1.005) | <0.001 | 1.675 (1.057–2.641) | 0.027 | ||
≥90 | 64/269 | 1.003 (1.001–1.005) | 0.003 | 0.343 | 2.317 (1.255–4.340) | 0.008 | 0.155 |
BMI, body mass index; CAD, coronary artery disease; DM, diabetes mellitus; SBP, systolic blood pressure; DBP, diastolic blood pressure.
Adjusted for propensity scores.