Table 3.

Association between insulin-like growth factor-1 and interventricular septal thickening in various subgroups.

Variables	Case/Number	Continuous, IGF–I	P-value	P for interaction	Categorical, T3 vs T1–2	P-value	P for interaction
		OR (95% CI)*			OR (95% CI)*
Age
18–44 years	21/105	1.006 (1.002–1.012)	0.010		3.775 (1.298–12.842)	0.021
45–59 years	71/323	1.003 (1.002–1.005)	<0.001		1.706 (0.970–3.011)	0.064
≥60 years	88/698	1.003 (1.001–1.005)	0.013	0.221	1.847 (1.035–3.252)	0.035	0.708
Sex
Male	116/479	1.003 (1.001–1.005)	<0.001		1.454 (0.925–2.280)	0.103
Female	64/324	1.003 (1.002–1.005)	<0.001	0.695	2.834 (1.545–5.229)	<0.001	0.099
Hypertension
No	40/174	1.004 (1.002–1.007)	<0.001		1.596 (0.737–3.441)	0.231
Yes	140/629	1.003 (1.001–1.004)	<0.001	0.181	1.896 (1.258–2.852)	0.002	0.770
DM
No	92/410	1.003 (1.002–1.005)	<0.001		1.835 (1.114–3.019)	0.017
Yes	88/393	1.003 (1.001–1.005)	<0.001	0.978	1.835 (1.084–3.095)	0.023	0.981
BMI
<28	101/499	1.004(1.002–1.006)	<0.001		1.567 (0.959–2.545)	0.07
≥28	79/304	1.002(1.001–1.004)	0.004	0.220	2.223 (1.293–3.843)	0.004	0.579
Acromegaly
No	156/763	1.003 (1.001–1.005)	0.002		1.484 (0.997–2.197)	0.05
Yes	24/40	1.000 (0.997–1.003)	0.872	0.047	–	0.985	0.981
CAD
No	134/638	1.003 (1.002–1.004)	<0.001		1.635 (1.083–2.465)	0.019
Yes	46/165	1.005 (1.001–1.010)	0.036	0.374	2.732 (1.265–5.942)	0.01	0.192
SBP (mmHg)
<140	78/398	1.004 (1.002–1.006)	<0.001		1.817 (1.038–3.160)	0.035
≥140	102/405	1.002 (1.001–1.004)	0.004	0.471	1.867 (1.158–3.013)	0.01	0.333
DBP (mmHg)
<90	116/534	1.004 (1.002–1.005)	<0.001		1.675 (1.057–2.641)	0.027
≥90	64/269	1.003 (1.001–1.005)	0.003	0.343	2.317 (1.255–4.340)	0.008	0.155

BMI, body mass index; CAD, coronary artery disease; DM, diabetes mellitus; SBP, systolic blood pressure; DBP, diastolic blood pressure.

^*Adjusted for propensity scores.