. 2022 Dec 7;13:1018938. doi: 10.3389/fmicb.2022.1018938

Table 4.

Performance of mNGS and conventional detection methods in patients with non-TB spinal infection.

Methods	Sensitivity	Specificity	PPV	NPV	p value	p value
Methods	(%, N, 95% CI)	(%, N, 95% CI)	(%, N, 95% CI)	(%, N, 95% CI)	(sensitivity)	(specificity)
mNGS	84.9% (45/53)	97.9% (46/47)	97.8% (45/46)	85.2% (46/54)	-	-
mNGS	(75–95)	(88–100)	(88–100)	(75–95)	-	-
Bacterial culture	15.4% (8/52)	100.0% (43/43)	100.0% (8/8)	49.4% (43/87)	χ² = 50.748	p = 1.000^a
Bacterial culture	(5–26)	(91–100)	(63–100)	(39–60)	p < 0.001^a	p = 1.000^a
Pathological examination	26.2% (11/42)	100.0% (37/37)	100.0% (11/11)	54.4% (37/68)	χ² = 33.381.	–
Pathological examination	(14–42)	(90–100)	(72–100)	(42–67)	p < 0.001^b	–

N: number of patients, PPV: positive predictive value, NPV: negative predictive value, CI: confidence interval, ^amNGS vs. bacterial culture, ^bmNGS vs. pathological examination