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. 2022 Dec 7;3:979038. doi: 10.3389/fpain.2022.979038

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© 2022 Nishida, Matsumura and Kobayashi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic showing proposed neural circuits in the shallow dorsal horn for visceral and somatic pain. Visceral pain preferentially evokes neuronal activities of marginal (lamina I) lamina neurons in the spinal dorsal horn whereas somatic pain does those of both marginal and deeper laminae neurons (lamina II and III). Brn3a-positive neurons in the marginal lamina are one of the populations which preferentially responded to visceral pain. These neurons were highly represented among supraspinal projection neurons innervating NTS (spino-solitary projection neurons) compared to those innervating LPb (spino-parabrachial projection neurons). Note that most spino-solitary projection neurons also innervate LPb (41).