Table 2.
Characteristics of 12 CpG sites showing different trajectories and/or levels in incident T2D
| CpG | CHR | BP position | Gene name | Location in gene | Relation to CpG-island | EWAS Atlas associations |
|---|---|---|---|---|---|---|
| cg06500161 | 21 | 43,656,587 | ABCG1 | Body | S_Shore | Blood triglyceride levels; body mass index (BMI); hypertriglyceridemic waist; metabolic syndrome (MetS); plasma fasting HOMA-IR levels; plasma fasting insulin levels; triglyceride postprandial responses to a high-fat dietary challenge; type 2 diabetes (T2D); waist circumference (WC); waist to height ratio (WHtR); waist to hip ratio (WHR); metabolic trait; blood high-density lipoprotein (HDL) levels; hepatic fat; insulin resistance |
| cg08994060 | 10 | 6,214,026 | PFKFB3 | Body | Aging, acute Lymphoblastic leukaemia; down syndrome; preeclampsia; prenatal mercury (Hg) exposure; type 2 diabetes (T2D); gestational age; inflamed Crohn’s disease (CD) | |
| cg15020801 | 17 | 46,022,809 | PNPO | Body | Cognitive function; smoking | |
| cg19693031 | 1 | 145,441,552 | TXNIP | 3'UTR | Alcohol consumption; blood HbA1c levels; diastolic blood pressure; down syndrome; inflammatory bowel disease; maternal smoking; metabolic syndrome (MetS); systolic blood pressure; type 2 diabetes (T2D); simple hepatic steatosis | |
| cg05778424 | 17 | 55,169,508 | AKAP1 | 5'UTR | Air pollution (NO2); multiple sclerosis; myalgic encephalomyelitis/chronic fatigue syndrome; type 2 diabetes (T2D) | |
| cg07504977 | 10 | 102,131,012 | N_Shelf | Body mass index (BMI); papillary thyroid carcinoma; puberty; waist circumference (WC); atopy; hormone therapy | ||
| cg11024682 | 17 | 17,730,094 | SREBF1 | Body | S_Shelf | Aging; blood triglyceride levels; body mass index (BMI); metabolic syndrome (MetS); myalgic encephalomyelitis/chronic fatigue syndrome; serum liver enzyme levels (gamma-glutamyl transferase, GGT); triglyceride postprandial responses to a high-fat dietary challenge; type 2 diabetes (T2D); waist circumference (WC); waist to height ratio (WHtR) |
| cg11202345 | 17 | 76,976,057 | LGALS3BP | 1stExon | Abdominal obesity; body mass index (BMI); preterm birth; waist circumference (WC) | |
| cg14476101 | 1 | 120,255,992 | PHGDH | Body | S_Shore | Aging; alcohol consumption; blood triglyceride levels; body mass index (BMI); diastolic blood pressure; maternal pre-pregnancy obesity; mortality; serum liver enzyme levels (gamma-glutamyl transferase, GGT); systolic blood pressure; type 2 diabetes (T2D); waist circumference (WC); waist to hip ratio (WHR); metabolic trait; atopy; hepatic fat; insulin resistance; SETD1B-related syndrome |
| cg18181703 | 17 | 76,354,621 | SOCS3 | Body | N_Shore | Aging; alcohol consumption; body mass index (BMI); cognitive function; Crohn's disease (CD); educational attainment; lung function; obesity; smoking; soluble tumor necrosis factor receptor 2 (sTNFR2) levels in plasma; type 2 diabetes (T2D); Werner syndrome; Nicolaides–Baraitser syndrome (NCBRS); insulin resistance; SETD1B-related syndrome; chemotherapy for breast cancer |
| cg19750657 | 13 | 38,935,967 | UFM1 | 3'UTR | Body mass index (BMI); obesity; preeclampsia; preterm birth; waist circumference (WC); plasma adiponectin levels | |
| cg26262157 | 10 | 6,214,079 | PFKFB3 | Body | Aging, Acute Lymphoblastic Leukemia; down syndrome; preeclampsia; prenatal mercury (Hg) exposure; type 2 diabetes (T2D); gestational age; inflamed Crohn's disease (CD) |