Table 2.

miRNA expression patterns significantly altered in df/ + /APP/PS1 and df/df compared to wild-type (+ / +) middle-aged mice as well as df/df/APP/PS1 middle-aged mice compared to df/ + /APP/PS1 middle-aged mice. p value and FDR < 0.05 were considered significant (refer to Supplemental Tables 7–9 for statistical values)

MicroRNA ID	df/ + /APP/PS1	df/df	df/df/APP/PS1
mmu-miR-1957a	↓	↑	-
mmu-miR-200b-3p	↓	↓	↑
mmu-miR-488-5p	-	↑	↑
mmu-miR-3078-5p	-	↑	↑
mmu-miR-412-5p	-	↑	↑
mmu-miR-298-5p	↑	↑	↑
mmu-miR-666-5p	-	↑	↑
mmu-miR-488-3p	-	↑	↓
mmu-miR-219b-3p	↑	↓	↓
mmu-miR-219a-5p	↑	↓	-
mmu-miR-29b-3p	↑	↑	↓
mmu-miR-342-5p	↑	↑	-
mmu-let-7b-3p	↑	-	↓
mmu-miR-451a	↑	-	↓
mmu-miR-1b-5p	↑	-	↓
mmu-miR-206-3p	↑	-	↓
mmu-miR-142a-3p	↑	-	↓
mmu-miR-669c-5p	↑	-	↓
mmu-miR-3065-5p	↑	-	↓
mmu-miR-1a-3p	↑	-	↓
mmu-miR-669a-5p	↑	-	↓
mmu-miR-669p-5p	↑	-	↓
mmu-miR-144-3p	↑	-	↓