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. 2022 Sep 24;44(6):2685–2699. doi: 10.1007/s11357-022-00662-9

Table 5.

Predicting physician-observed morbidity, lung capacity, and subjective health from five different alternative age indices in the Berlin Aging Study II: shared and unique effects

Predictors Model 1 Model 2 Model 3 Model 4 Model 5 Model 6 Conjoint model
Physician-observed morbidity
Chronological age .007 .002 .019 –.039 .066* –.009 –.031
Women –.068* –.053 .034 –.069* –.058 –.034 .024
Education –.018 –.030 –.006 –.032 –.029 –.002 .049
Telomere length –.029 –– –– –– –– –– –.018
DNA meth1 –– –.058 –– –– –– –– .053
PhenoAge –– –– .224* –– –– –– .232*
Biological age –– –– –– .145* –– –– .013
Skin age –– –– –– –– –.014 –– .047
Subjective age –– –– –– –– –– –.048 .021
Total R2 .005 .008 .047 .023 .009 .003 .065
F 1.35 2.31 12.11* 7.07* 2.30 0.89 3.76*
(df1, df2) (4, 1164) (4, 1172) (4, 976) (4, 1205) (4, 987) (4, 1127) (9, 687)
Lung capacity
Chronological age –.210* –.220* –.191* –.191* –.220* –.223* –.177*
Women –.710* –.704* –.756* –.709* –.715* –.715* –.795*
Education .033 .044 .000 .047 .050 .021 –.018
Telomere length –.004 –– –– –– –– –– –.057
DNA meth1 –– .003 –– –– –– –– –.037
PhenoAge –– –– –.094* –– –– –– –.038
Biological age –– –– –– –.023 –– –– .001
Skin age –– –– –– –– .005 –– .013
Subjective age –– –– –– –– –– –.018 .049
Total R2 .544 .548 .578 .556 .554 .556 .559
F 175.34* 179.66* 166.59* 188.46* 144.54* 179.58* 39.39*
(df1, df2) (4, 587) (4, 594) (4, 492) (4, 603) (4, 466) (4, 573) (9, 245)
Subjective health
Chronological age –.025 –.026 ,014 –.034 –.063* .137* .033*
Women –.090* –.086* –.126* –.055* –.033 –.072* –.076
Education –.000 –.020 .045 .014 .022 –.009 .046
Telomere length –.019 –– –– –– –– –– –.024
DNA meth1 –– .001 –– –– –– –– –.021
PhenoAge –– –– –.141* –– –– –– –.147*
Biological age –– –– –– –.101* –– –– –.004
Skin age –– –– –– –– .076* –– .015
Subjective age –– –– –– –– –– –.289* –.186*
Total R2 .008 .008 .027 .011 .009 .066 .055
F 2.42* 2.41* 7.19* 3.72* 2.47* 21.59* 3.34*
(df1, df2) (4, 1107) (4, 1111) (4, 1039) (4, 1125) (4, 893) (4, 1060) (9, 526)

DNA meth, DNA methylation age. Standardized prediction effects (β). a p = .07, b p = .05, * p < .05

Intercorrelations in bold differ significantly from zero at p < .05