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. 2022 Oct 19;44(6):2925–2931. doi: 10.1007/s11357-022-00671-8

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Fig. 2 — A meta-analysis of multiple trials of anti-resorptive treatments for osteoporosis demonstrated a strong (R² = 0.73) correlation between absolute amount of increase in total hip bone density (BMD) and odds ratio of reduction in risk of hip fracture. This established change in BMD as a valid surrogate marker for the effect of treatment on risk of fracture