Table 1.
Characteristics of patients with necrotizing soft tissue infections (n = 170) at intensive care unit admission
| N | Total | |
|---|---|---|
| N = 170 | ||
| Demographic data | ||
| Age | 170 | 59 [53–68.8] |
| Sex | 170 | |
| Male | 122 (71.8) | |
| Female | 48 (28.2) | |
| NSTI characteristics | ||
| Hospital-acquired NSTI | 170 | 38 (22.4) |
| Topography | ||
| Upper limb | 170 | 24 (14.1) |
| Lower limb | 170 | 121 (71.2) |
| Abdominal/perineal | 170 | 33 (19.4) |
| Multifocal | 170 | 8 (4.7) |
| Comorbidities | ||
| Immunosuppressiona | 170 | 43 (25.3) |
| Cancer | 43 | 14 (32.5) |
| Neutropenia | 43 | 5 (11.6) |
| HIV infection | 43 | 4 (9.3) |
| Long-term corticosteroids | 43 | 26 (60.5) |
| PAOD | 170 | 26 (15.3) |
| Diabetes | 170 | 94 (55.3) |
| Chronic heart failure | 170 | 38 (22.4) |
| COPD | 169 | 17 (10.1) |
| Cirrhosis | 169 | 15 (8.9) |
| Chronic hemodialysis | 170 | 5 (2.9) |
| Chronic alcohol intoxication | 170 | 49 (28.8) |
| NSAIDs use before hospitalization | 168 | 37 (22.0) |
| Obesity | 170 | 60 (35.3) |
| Microbiological data | ||
| Number of isolated bacteria | 156 | 2 [1–3] |
| NSTI categorization | 154 | |
| Type II (monomicrobial) | 65 (42.2) | |
| Type I (polymicrobial) | 89 (57.8) | |
| Positive blood culture | 170 | 50 (29.4) |
| Isolation of multi / highly resistant bacteria | 168 | 29 (17.3) |
| Severity scores and organ failures | ||
| SAPS II | 161 | 46 [30–63] |
| SOFA | 161 | 8 [4–12] |
| Organ failures within the first 24 h of ICU admission | 163 | 115 (70.6) |
| Invasive mechanical ventilation support | 163 | 55 (33.7) |
| Vasopressor support | 163 | 113 (69.3) |
| Renal replacement therapy | 163 | 35 (21.5) |
| Post-surgical ICU admission | 163 | 48 (29.5) |
Qualitative variables are shown as number (percentages) and continuous variables as median [quartile 1-quartile 3]
PAOD peripheral artery occlusive disease, HIV human immunodeficiency virus, COPD chronic obstructive pulmonary disease, NSAIDs non-steroidal anti-inflammatory drugs, NSTI necrotizing soft tissue infection, SAPS Simplified Acute Physiology Score, SOFA Sequential Organ Failure Assessment score
aThe sum of the subgroups can be greater than 100% because patients can accumulate several criteria