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. 2022 Jul 28;44(6):2863–2884. doi: 10.1007/s11357-022-00625-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Comparative proteomic analysis of proteomes of EVs secreted by control and senescent VSMCs. a Pie charts presenting the distribution of fold changes (FC) in the level of proteins identified in EVs secreted by senescent cells relative to EVs from control cells (p < 0.05). b Venn diagrams of up and downregulated proteins identified in EVs from SIPS and RS cells that were significantly changed (p < 0.05); c Reactome pathway analysis of proteins that were upregulated (FC > 1.3) or downregulated (FC < 0.7) in EVs secreted by senescent VSMCs (SIPS and RS) comparing to EVs from young VSMCs. EVs from three independent biological experiments for each condition (control, SIPS, and RS) were subjected into proteomic analysis