Table 1.

List of significantly upregulated proteins, identified in EVs secreted by senescent VSMCs, that were annotated to Immune System Process (GO:0,002,376) category; proteins that are upregulated at > 1.3- fold level are marked in bold; SIPS – stress induced premature senescence, RS – replicative senescence

Immune System Process
SIPS and RS	only SIPS	only RS
SERPINC1, KRT-16, HTRA1, THBS1, GAS6, FGB, DYNC1LI2, MME, PYGL, VIM, SERPINE1, PRDX2, PGM1, GSN, GLB1, CTSB, KIF5B, DPP4, GPX1, DYNC1H1, LRP1, ACTR1A, CLTC, NECTIN2, RAB6A, ITGB3, DCTN1, TNFRSF10B, FLNA, CKAP4	WNT5A, A2M, DNM2, CLU, C5, HBB, THBS4, PRKG1, CAPN1, PTX3, PSMB8, AIMP1, PXDN, ACTN1, RRAS, COL1A1, ZYX, DSC1, PFKL, GREM1, KLC1, FTL, ALDOC, COL1A2, APOA4, AP2B1, C1R, SEC31L1, FTH1, C1S, TUBB, DCTN2, PKM, XRCC6, DYNC1LI1, C3, OXSR1, ANPEP, AHCY, SSC5D, MTHFD1, PSMC2, PSMD1, PSMD12, EMILIN1, CCT2, PSMC5, VAT1	ARG1, PRSS3, TXNDC5, CAT, HRNR, CALR, PDIA3, CANX, CTSD, DSG1, CTSA, HEXB, PRDX1, PARK7, PRNP, PSMD4, APOB, PBEF1, SEC22B, PRDX3, VCP, HSPA9, PGM3, FLNB, VCL, APEH

bold:FC>1,3