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. 2022 Dec 20;13:7617. doi: 10.1038/s41467-022-35309-y

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© The Author(s) 2022, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Graphical abstract showing the effect of AR in the development of colitis. AR disrupts the intestinal epithelial barrier integrity via MLCK and mucus layer, while AR also stimulates colonic 5-HT secretion, modulates the gut microbiota composition, and promotes colitis. Under GF conditions, AR also induces colonic 5-HT secretion, which primes for inflammatory reactions.