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. 2022 Dec 20;8:49. doi: 10.1038/s41540-022-00257-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Pearson correlation coefficients between measured and predicted exchange fluxes. The objective in all simulations in this figure is ammonia. The reactions on the x axis—SHM, FBP, etc.—represents the effect of overexpression of the respective genes on the predicted fluxes and the resulting Pearson correlation with the measured exchange fluxes. The asterisk * indicates significance. B Relative changes in predicted fluxes (%) for activity of SHM and AMT genes in all pathways. Boxplots show the gene expression levels of significantly altered genes in the rat.