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. 2022 Dec 7;13:1059042. doi: 10.3389/fimmu.2022.1059042

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Copyright © 2022 Gui, Cheng, Zhou, Xu, Han and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The functions of CD8αα IELs. TCRαβ⁺ CD8αα⁺ IELs express Ly49A, Ly49C, Ly49E, and other genes of the Ly49 family, as well as 2B4, fibrinogen-like protein-2, TGF-β3, and LAG-3, being involved in immune regulation. In contrast to TCRαβ⁺ CD8αα⁺ IELs, TCRγδ⁺ IELs express TGFβ1, TGFβ3, prothymosin β4, heat shock proteins, chemokine KC, and βig-h3, being involved in injury healing and protection of the integrity of epithelium. Meanwhile, these cells could also express cytokines KC, IL-1β, MIP2α, Cxc19, and Cxc116 thus recruiting various inflammatory cells. Besides, they are characterized by a specific dynamic pattern to surveil and respond to pathogen invasion, undertaking diverse roles in the intestine.