Table 1.
Clinical information on patients with OXA-48 carbapenemase.
| Patient | CPE | Sex | Age | Main diagnosis | Isolation date | Date of admission | Date of dischearge | Hospitalization days | Antibiotic susceptibility testing | Colonization | Decolonization method | CPE decolonization | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Susceptible phenotype | Resistant phenotype | ||||||||||||
| Patient 1 | C. freundii P7700 | M | 59 | Lung adenocarcinoma | 18/12/2016 | 21/11/2016 | 30/12/2016 | 39 | FOF, AK, FEP, ERT (1), IPM (1) | AMX, AMC, CRO, TPZ, CIP, DO, GEN, SXT | U | Dead before FMT | / |
| Patient 2 | C. freundii P7702 | F | 64 | Recurrent hemoptysis | 17/08/2017 | 14/08/2017 | 27/10/2017 | 74 | FOF, AK, FEP, ERT (0.5), IPM (0.5) | AMX, AMC, CRO, TPZ, CIP, DO, GEN, SXT | R/U | FMT by gastric way (2 times) | Failure of the first attempt but success of the second |
| Patient 3 | E. hormaechei P7535 | F | 73 | Lung adenocarcinoma | 27/10/2017 | 10/10/2017 | 19/12/2017 | 40 | FOF, AK, GEN, FEP, DO, SXT | AMX, AMC, CRO, TPZ, CIP, ERT (2), IPM (2) | R | FMT by gastric way | Success |
| Patient 4 | C. freundii P7699 | F | 56 | Urothelial carcinoma | 22/11/2017 | 12/11/2017 | 02/12/2017 | 20 | FOF, AK, FEP, ERT (1), IPM (1) | AMX, AMC, CRO, TPZ, CIP, DO, GEN, SXT | R | FMT by gastric way | Success |
| Patient 5 | E. hormaechei P7538 | M | 71 | Laryngeal carcinoma | 22/11/2017 | 11/11/2017 | 15/12/2017 | 34 | FOF, AK, ERT (1), IPM (1) | AMX, AMC, CRO, TPZ, CIP, FEP, DO, SXT, GEN | R/C | FMT by gastric way | Failure |
| Patient 6 | E. cloacae P7536 | F | 28 | Pleurisy on gastropleural fistula | 30/11/2017 | 13/11/2017 | 17/12/2017 | 34 | FOF, AK | AMX, AMC, CRO, TPZ, CIP, FEP, DO, SXT, GEN, ERT (4), IPM (2) | R | FMT by rectal way | Failure |
| Patient 7 | C. freundii P7697 | F | 57 | Lung adenocarcinoma | 7/12/2017 | 27/11/2017 | 13/12/2017 | 16 | FOF, AK, FEP, ERT (1), IPM (1) | AMX, AMC, CRO, TPZ, CIP, DO, GEN, SXT | R/U | FMT by gastric way | Success |
| E. hormaechei P7537 | FOF, AK, FEP, DO, SXT, GEN | AMX, AMC, CRO, TPZ, CIP, ERT (2), IPM (2) | |||||||||||
| Patient 8 | E. hormaechei P7698 | M | 63 | Small cell lung carcinoma | 7/12/2017 | 18/11/2017 | 16/12/2017 | 28 | FOF, AK | AMX, AMC, CRO, TPZ, CIP, FEP, DO, SXT, GEN, ERT (>32), IPM (6) | R/U/C | Dead before FMT | / |
CPE, Carbapenemase-producing Enterobacteriaceae; R, Rectal; U, Urinary; C, Cutaneous; FMT, Fecal Microbiota Transplantation; FOF, fosfomycin; AK, amikacin; AMX, amoxicillin; AMC, amoxicillin-clavulanic acid; CRO, ceftriaxone; TPZ, piperacillin-tazobactam; CIP, ciprofloxacin; FEP, cefepime; DO, doxycycline; SXT, trimethoprim-sulfamethoxazole; GEN, gentamicin; ERT, ertapenem; IPM, imipenem; (MIC en µg/mL).