TABLE 1.

Nucleotide and amino acid variants within the gene and mature protein of the CSN2.

Encoded protein variant	Protein/DNA variant name	Position on chr 6 (bp) a	86,008,407	86,008,401	86,008,103	86,008,049	86,008,047	86,008,016	86,007,341/86,007,342	86,006,394	References
		Position on the gene	Exon 7	Exon 7	Exon 7	Exon 7	Exon 7	Exon 7	Exon 8	Exon 9 (3′ UTR)
		Amino acid position b	47	58	148	166	167	177	207
CSN2*C	CSN2*C	NC_030813	C	T	G	G	G	A	AC	G	Wang et al. (2001); Neveu et al. (2002); Bickhart et al. (2017)
		XP_005681778	Asp	Leu	Pro	Ser	Q	Val	Val
CSN2*A	CSN2*A	CSN2*A_Gen.						G			Roberts et al. (1992), Rando (1998)
		CSN2*A_Prot.						Ala
CSN2*A	CSN2*A1	CSN2*A1_Gen.								A	Cosenza et al. (2005)
		CSN2*A1_Prot.
CSN2*B	CSN2*B*	CSN2*B_Gen.									NCD; Mahé and Grosclaude (1993)
		CSN2*B_Prot.
CSN2*C	CSN2*C1	CSN2*C1_Gen.								A	Chessa et al. (2008)
		CSN2*C1_Prot.
CSN2*C	CSN2*C2**	CSN2*C2_Gen.								A	Nicolai et al. (2021)
		CSN2*C2_Prot.
CSN2*D	CSN2*D	CSN2*D_Gen.							TT		NCD; Galliano et al. (2004)
		CSN2*D_Prot.							Asn
CSN2*E	CSN2*E	CSN2*E_Gen.				T					Caroli et al. (2006)
		CSN2*E_Prot.				Tyr
CSN2*F	CSN2*F (CSN2*E)	CSN2*F_Gen.	A								NCD; Chianese et al. (2007); Moatsou et al. (2007)
		CSN2*F_Prot.	Thr
CSN2*F	CSN2*F1	CSN2*F1_Gen.	A							A	Nicolai et al. (2021)
		CSN2*F1_Prot.	Thr
CSN2*G	CSN2*G (CSN2*F)	CSN2*G_Gen.			A						Rahmatalla et al. (2021)
		CSN2*G_Prot.			Leu
CSN2*0	CSN2*0	CSN2*0_Gen.		Del_T							Persuy et al. (1999)
		CSN2*0_Prot.		Stop codon	NT	NT	NT	NT	NT
CSN2*0	CSN2*0'	CSN2*0'_Gen.					A				Rando et al. (1996), Boulanger et al. (1984)
		CSN2*0'_Prot.					Stop codonc	NT	NT

^a Chromosomal position in base pairs (bp) in the positive strand according to the goat genome reference version LWLT01, which represent CSN2*C.

^b Amino acids position according to the reference protein sequence XP_005681778. The whole sequence of 257 amino acids comprises 207 of the mature protein. All the amino acid position based on the mature protein.

*: Variant CSN2*B migrates faster under alkaline pH and slower in acid pH and there is difference in mobility compared to variant CSN2*A

**: CSN2*C2 coding for the same amino acid sequence as variant CSN2*C1, but it was lower the amount of the expressed protein.

^c The nucleotide mutation generates a stop codon.

Mutations in the 3'UTR are shown in italics and bold and non-synonymous mutations are shown in normal font.

Del= deletion, NCD = Not characterized at the DNA level.

NT: Not translated after stop codon.

The name of the old variant are given in parentheses.