Figure 3.

In silico study and annotation. (A) The DEPs were used to map the pathways involved in the pathogenesis of osteoarthritis (OA). The pathways are depicted by the colored circle, where the size of the circle indicates the number of proteins and the color of the circle indicates the p-value. (B) The GO annotation tool was used to determine the molecular and functional roles of the identified DEPs. The number of proteins involved in biological processes, molecular functions, and cell components are shown in green, red, and black, respectively. The top 10 GO entries with p ≤ 0.05 are depicted. DEPs, differentially expressed proteins; GO, Gene Ontology; ECM, extracellular matrix.