Table 1.

Highly differentially expressed proteins (upregulated ≥3-fold and downregulated ≤0.35-fold) identified using an isobaric tag for relative and absolute quantitation (iTRAQ) and sequential window acquisition of all theoretical mass spectra (SWATH-MS).

No.	Name	Fold change
Highly upregulated differential proteins (≥3-fold)
1	Alpha-1-acid glycoprotein 1	4.28E+00
2	Fibrinogen alpha chain	5.44E+00
3	Leucine-rich alpha-2-glycoprotein	9.46E+00
4	Alpha-1-antitrypsin	4.58E+00
5	Vitamin D-binding protein	3.13E+00
6	Apolipoprotein A-II	3.00E+00
7	Histidine-rich glycoprotein	3.66E+00
8	N-acetylmuramoyl-l-alanine amidase	5.15E+00
9	Immunoglobulin kappa constant	7.18E+00
10	Angiotensinogen	6.39E+00
11	Heparin cofactor 2	4.41E+00
12	Complement component C8 gamma chain	5.00E+00
13	APOC4–APOC2 readthrough (NMD candidate)	3.36E+00
14	Ficolin-3	3.14E+00
15	Immunoglobulin kappa variable 3-15	6.67E+00
16	Complement factor H-related protein 1	6.36E+00
17	Properdin	4.55E+00
18	Trypsin-1 (fragment)	6.15E+00
19	IgGFc-binding protein (fragment)	3.43E+00
20	Immunoglobulin heavy variable 3-13	3.25E+00
21	Bridging integrator 3	4.09E+00
22	Probable helicase with zinc finger domain	3.81E+00
23	Beta-2-microglobulin (fragment)	9.14E+00
24	Transcription factor Sp5	7.06E+00
Highly downregulated differential proteins (≤0.35-fold)
1	Complement C3	1.59E−01
2	Hemoglobin subunit beta	1.60E−01
3	Apolipoprotein A-IV	3.47E−01
4	Coagulation factor XIII A chain	2.38E−01
5	Serotransferrin	1.31E−01
6	cDNA FLJ55673, highly similar to complement factor B	3.13E−01
7	Prothrombin	1.94E−01
8	Inter-alpha-trypsin inhibitor heavy chain H1	3.55E−01
9	Apolipoprotein C-I (fragment)	2.33E−01
10	Complement C1r subcomponent-like protein	2.71E−01
11	Complement C2	2.68E−01
12	Serum amyloid A protein	2.90E−01