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. 2022 Dec 7;13:1017164. doi: 10.3389/fimmu.2022.1017164

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Copyright © 2022 Martin-Gayo, Gao, Calvet-Mirabent, Ouyang, Lichterfeld and Yu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of potential upstream regulators for the high responder EC. (A, B) Selected upstream regulators of DEG distinguishing high responder (HR-EC) vs low responder (LR-EC) EC subgroups, as determined by Ingenuity Pathway Analysis. Data reflect all immune pathways (left) or only molecules with enzymatic activity (right). Molecules with a predicted positive upstream effect are highlighted in red, while molecules with a predicted negative effect are in blue. (C) Network interaction of selected upstream regulators identified in (A) (right panel) highlighting relevant genes within interaction nodes (red) and connecting genes (pink) as well as individual gene targets (violet). Zooms on the central Gene Nodes are displayed in the left panel. (D) Analysis of Betweenness and Node scores of upstream regulator genes included within network defined in (C).