Table 2.
Haplotype analysis of WNT pathway genes in PTB patients and controls.
| Haplotype | PTB [n(%)] | Controls [n(%)] | P value | OR (95% CI) |
|---|---|---|---|---|
| SFRP1 rs10088390-rs4736958-rs3242 | ||||
| CTA | 26.95 (3.0) | 34.30 (3.70) | 0.415 | 0.808(0.484, 1.350) |
| CTG | 516.44 (57.1) | 535.24 (57.6) | 0.991 | 0.999(0.827, 1.207) |
| GCG | 285.30 (31.6) | 293.36 (31.5) | 0.913 | 1.011(0.829, 1.233) |
| GTG | 46.66 (5.2) | 43.93 (4.7) | 0.641 | 1.106(0.724, 1.688) |
| WNT3A rs752107-rs3121310 | ||||
| CA | 142.00 (15.7) | 128.35 (13.8) | 0.259 | 1.161(0.896, 1.503) |
| CG | 545.00 (60.3) | 567.65 (61.0) | 0.692 | 0.963(0.798, 1.161) |
| TA | 217.00 (24.0) | 231.65 (24.9) | 0.630 | 0.949(0.767, 1.174) |
| CTNNB1 rs2293303-rs1798802-rs4135385 | ||||
| CAA | 158.80 (17.6) | 161.35 (17.3) | 0.889 | 1.017(0.799, 1.295) |
| CGA | 154.24 (17.1) | 157.96 (17.0) | 0.951 | 1.008(0.790, 1.286) |
| CGG | 453.23 (50.1) | 495.57 (53.3) | 0.188 | 0.884(0.735, 1.062) |
| TAA | 130.44 (14.4) | 109.22 (11.7) | 0.085 | 1.270(0.967, 1.668) |
| WIF-1 rs1026024-rs3782499 | ||||
| AT | 158.96 (17.6) | 183.03 (19.8) | 0.228 | 0.865(0.684, 1.095) |
| GC | 165.96 (18.4) | 163.93 (18.2) | 0.914 | 1.013(0.799, 1.284) |
| GT | 579.04 (64.1) | 577.07 (6.21) | 0.375 | 1.090(0.901, 1.317) |
| DKK-1 rs2241529-rs1569198 | ||||
| AA | 600.60966.4) | 626.80 (67.4) | 0.692 | 0.961(0.791, 1.169) |
| GA | 104.40 (11.5) | 77.20 (8.3) | 0.019 | 1.445(1.060, 1.969) |
| GG | 195.59(21.6) | 223.80 (24.1) | 0.221 | 0.873(0.701, 1.086) |
| LRP5 rs3736228-rs556442 | ||||
| CA | 667.84 (73.9) | 660.92 (71.1) | 0.164 | 1.157(0.942, 1.442) |
| CG | 68.16 (7.5) | 69.08 (7.4) | 0.921 | 1.018(0.719, 1.441) |
| TG | 165.84 (18.3) | 198.92 (21.4) | 0.105 | 0.827(0.657, 1.041) |
| LRP6 rs2302685-rs11054697-rs10743980 | ||||
| CTT | 56.70 (1.4) | 56.32 (6.1) | 0.860 | 1.035(0.707, 1.515) |
| TCT | 68.59 (7.6) | 85.76 (9.2) | 0.200 | 0.805(0.578, 1.122) |
| TTC | 669.13 (7.4) | 673.08 (72.4) | 0.476 | 1.081(0.873, 1.337) |
| TTT | 91.83 (10.2) | 93.92 (10.2) | 0.983 | 1.003(0.740, 1.359) |
Frequency < 0.03 in both controls & PTB patients has been dropped.
Bold value means P < 0.05.