Table 1.

General search strategy (A) and search strategy logic by database (B) for the systematic review on the effect of pre-, pro-, and synbiotics on gastrointestinal outcomes in healthy adults and healthy active adults.

(A) Field one (combine with OR): Population		Field two (combine with OR): Intervention and comparison		Field three (combine with OR): Outcome
Keywords: Exercise, Run*, Cycling, Cyclist, Physical Activity	AND	Keywords: probiotic, prebiotic, synbiotic	AND	Keywords:, intestinal injury and damage, I-FABP, intestinal fatty acid, tight junction, mucosal barrier, zonulin, claudin, endotoxin, LPS, LAL, lipopolysaccharide, gram negative bacteria, LBP, sCD14, intestinal permeability, lactulose, rhamnose, mannitol, urinary sugars, gastrointestinal motility, OCTT, EGG, gastrointestinal symptoms, gut discomfort, short chain fatty acids, SCFA, gastrointestinal microbiota and microbial composition.
(B) OVID EMBASE and Ovid MEDLINE(R) and Epub Ahead of Print
1.	(Exercise or Run* or Cycling or Cyclist or “Physical Activity”).mp. (mp = title, abstract, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword heading word, floating subheading word, candidate term word)
2.	(probiotic or prebiotic or synbiotic).mp. (mp = title, abstract, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword heading word, floating subheading word, candidate term word)
3.	(“intestinal injury” or “intestinal damage” or I-FABP or “intestinal fatty acid” or “tight junction” or “mucosal barrier” or zonulin or claudin or endotoxin or LPS or LAL or lipopolysaccharide or “gram negative bacteria” or LBP or sCD14 or “intestinal permeability” or lactulose or rhamnose or mannitol or “urinary sugars” or “gastrointestinal motility” or OCTT or EGG or “gastrointestinal symptoms” or “gut discomfort” or “short chain fatty acid*” or SCFA or microbiota or “microbial composition”).mp. (mp = title, abstract, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword heading word, floating subheading word, candidate term word)
4.	1 and 2 and 3
SCOPUS
	(TITLE-ABS-KEY (exercise OR run* OR cycling OR cyclist OR {physical activity}) AND TITLE-ABS-KEY (probiotic OR prebiotic OR synbiotic) AND TITLE-ABS-KEY ({intestinal injury} OR {intestinal damage} OR i-fabp OR {intestinal fatty acid} OR {tight junction} OR {mucosal barrier} OR zonulin OR claudin OR endotoxin OR lps OR lal OR lipopolysaccharide OR {gram negative bacteria} OR lbp OR scd14 OR {intestinal permeability} OR lactulose OR rhamnose OR mannitol OR {urinary sugars} OR {gastrointestinal motility} OR octt OR egg OR {gastrointestinal symptoms} OR {gut discomfort} OR {short chain fatty acid*} OR scfa OR microbiota OR {microbial composition}))
CINAHL plus and SPORTDiscus with full text
S7	S1 AND S2 AND S6
S6	S3 OR S4 OR S5
S5	gut discomfort OR short chain fatty acid* OR SCFA OR microbiota OR microbial composition
S4	gram negative bacteria OR LBP OR sCD14 OR intestinal permeability OR lactulose OR rhamnose OR mannitol OR urinary sugars OR gastrointestinal motility OR OCTT OR EGG OR gastrointestinal symptoms
S3	intestinal injury OR intestinal damage OR I-FABP OR intestinal fatty acid OR tight junction OR mucosal barrier OR zonulin OR claudin OR endotoxin or LPS or LAL or lipopolysaccharide
S2	probiotic OR prebiotic OR synbiotic
S1	exercise OR run* OR cycling OR cyclist* OR physical activity
Web of science
	Exercise OR run* OR cycling OR cyclist OR “physical activity” (Topic) and probiotic or prebiotic or synbiotic (Topic) and “intestinal injury” or “intestinal damage” or I-FABP or “intestinal fatty acid” or “tight junction” or “mucosal barrier” or zonulin or claudin or endotoxin or LPS or LAL or lipopolysaccharide or “gram negative bacteria” or LBP or sCD14 or “intestinal permeability” or lactulose or rhamnose or mannitol or “urinary sugars” or “gastrointestinal motility” or OCTT or EGG or “gastrointestinal symptoms” or “gut discomfort” or “short chain fatty acid*” or SCFA or microbiota or “microbial composition” (Topic)

^*Used to retrieve unlimited suffix variations.