Figure 4.

iRGCs show transcriptional similarities to a subset of RGCs from fetal retinas

(A) Combined UMAP plot of day 59 fetal retina, day 82 fetal retina, and iRGCs shows 14 clusters, representing at least four main retinal cell types identified by typical markers shown in dot plots.

(B) Focusing on the RGC segment (boxed in A), UMAP plotted by tissue of origin suggests that iRGCs form a unique subtype closest to cluster 1- and cluster 5-type RGCs found in fetal retinas of both ages.

(C) Heatmap of genes (black) driving cluster separation among clusters 1, 5, and 10, demonstrating the few differences (blue) between fetal RGCs and iRGCs.

(D) Functional enrichment of genes that are significantly expressed in fetal RGCs and iRGCs.