Figure 3.

Urine metabolome prediction model using nine metabolites sampled early in gestation validates on the validation cohort

Samples obtained in the first 16 weeks of pregnancy are used.

(A) AUC = 0.83, 95% CI [0.62, 1] and prediction values (scores) obtained by EN for preeclamptic (PE) and normotensive women.

(B) Metabolites identified by EN as biomarkers of preeclampsia. y axis shows the value in early pregnancy stratified by normotensive (gray) and preeclamptic (light blue) pregnancies. p values obtained using Wilcoxon signed-rank univariate analysis show statistical significance of each protein (∗p ≤ 0.05, ∗∗p ≤ 0.01, ∗∗∗p ≤ 0.001).