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. 2022 Dec 18;8(4):20552173221144230. doi: 10.1177/20552173221144230

Figure 2.

Figure 2.

Rolling regression models of baseline MRI measures and clinical variables across ages. Rolling multiple regression models of how baseline MRI brain volume fractions and lesion volumes associate with clinical variables across different ages of the persons with MS. Due to a larger sample size, a bandwidth of 100 persons was used for the EDSS rolling regressions, while a bandwidth of 30 persons was used for the other clinical variables. Stepwise reduction of multiple regression models including the entire age span of persons was used for covariate selection. MS subtype (relapsing-onset vs primary progressive MS) was not included as a covariate due to too few cases of primary progressive MS. The colored vertical bars represent the 95% confidence intervals for each regression. Abbreviations: DMT, Disease-modifying treatment; EDSS, expanded disability status scale; MRI, magnetic resonance imaging; MS, multiple sclerosis; MSIS-29, MS impact scale 29; SDMT, symbol digit modalities test. (a) EDSS. N = 441. Age at onset was used as a covariate. (b) SDMT. N = 148. MRI scanner was used as a covariate. (c) MSIS-29 physical. N = 190. Age at onset, sex, MRI scanner and platform DMT exposure were used as covariates. (d) MSIS-29 psychological. N = 190. MRI scanner was used as a covariate.