Skip to main content
. 2022 Dec 18;8(4):20552173221144230. doi: 10.1177/20552173221144230

Figure 3.

Figure 3.

Forest plot of linear mixed-effects models of longitudinal clinical measures and baseline MRI measures with time interaction. In all models, study subjects and MRI scanners were used as nested random effects with random slopes at time of measurement of the clinical scores. The asterisks represent p-values after false discovery rate correction. *p < 0.05; **p < 0.01; ***p < 0.001. No asterisk(s)p ≥ 0.05. The CIs were not corrected for multiple comparisons. Abbreviations: CI, confidence interval; DMT, disease-modifying treatment; EDSS, expanded disability status scale; FLAIR, fluid-attenuated inversion recovery; MRI, magnetic resonance imaging; MSIS-29, multiple sclerosis impact scale 29; SDMT, symbol digit modalities test. EDSS: N = 672. There were 5515 EDSS scores. Baseline age at MRI, age at onset, disease type (relapsing-onset vs primary progressive multiple sclerosis), highly active DMT exposure, MRI measure, time after baseline clinical examination and an MRI measure*time interaction term were used as fixed effects. SDMT: N = 779. There were 6011 SDMT scores. Baseline age at MRI, age at onset, total number of completed SDMTs, FLAIR sequence type (2D vs 3D), disease type (relapsing-onset vs primary progressive multiple sclerosis), highly active DMT exposure, MRI measure, time after baseline clinical examination and an MRI measure*time interaction term were used as fixed effects. MSIS-29 physical: N = 820. There were 5497 MSIS-29 physical scores. Baseline age at MRI, baseline age at clinical examination, age at onset, sex, FLAIR sequence type (2D vs 3D), disease type (relapsing-onset vs primary progressive multiple sclerosis), platform and highly active DMT exposure, MRI measure, time after baseline clinical examination and an MRI measure*time interaction term were used as fixed effects. MSIS-29 psychological: N = 820. There were 5497 MSIS-29 psychological scores. Baseline age at MRI, age at onset, sex, disease type (relapsing-onset vs primary progressive multiple sclerosis), platform and highly active DMT exposure, MRI measure, time after baseline clinical examination, and an MRI measure*time interaction term were used as fixed effects.