Table 6.

Compositional data, intake values (calculated for cats at 0.2 mg/kg complete feed), reference points and margin of exposure (MOE) for the individual components of asafoetida oil classified according to assessment groups

Essential oil composition		Exposure		Hazard characterisation		Risk characterisation
Assessment group	Highest conc. in the oil	Highest feed conc.	Daily intake (a)	Cramer class (b)	NOAEL	MOE	MOET
Constituent	%	mg/kg	mg/kg bw/day	–	mg/kg bw/day	–	–
CG 20
(E)‐2‐Butyl 3‐(methylthio)‐2‐propenyl disulfide	40.10	0.080	0.0018	(III)	7.3	4,005
(E)‐sec‐Butyl propenyl disulfide	16.00	0.032	0.0007	(III)	7.3	10,038
(Z)‐sec‐Butyl propenyl disulfide	15.50	0.031	0.0007	(III)	7.3	10,361
di‐sec‐Butyl disulfide	12.60	0.025	0.0006	(I)	7.3	12,746
(Z)‐1‐(Methylthio)propyl 1‐propenyl disulfide	10.50	0.021	0.0005	(III)	7.3	15,295
(E)‐1‐(Methylthio)propyl 1‐propenyl disulfide	7.07	0.014	0.0003	(III)	7.3	22,716
MOET CG 20							1,578

^(a)Intake calculations for the individual components are based on the use level of 0.2 mg/kg in feed for cat. The MOE for each component is calculated as the ratio of the reference point (NOAEL) to the intake. The combined margin of exposure (MOET) is calculated for each assessment group as the reciprocal of the sum of the reciprocals of the MOE of the individual substances.

^(b)When a NOAEL value is available or read‐across is applied, the allocation to the Cramer class is put into parentheses.