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Based on Monte Carlo simulations of the intravenous dosage regimens administered in the study. PK-PD targets used: fAUC/MIC ≥34 for S. pneumoniae and fAUC/MIC ≥75 for Gram-negative bacteria.
fAUC/MIC, area under the free concentration-time curve in a 24-hour interval/minimum inhibitory concentration; PK-PD, pharmacokinetic-pharmacodynamic
