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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: Nat Neurosci. 2022 Jul 28;25(8):1071–1081. doi: 10.1038/s41593-022-01126-1

Figure 3. Introducing novelty via a context switch abolishes the dopamine signatures of latent inhibition.

Figure 3.

(a) Mice (n=7 mice; 4 males, 3 females) underwent four sessions of pre-exposure in context A. Dopamine responses were recorded in two subsequent fear conditioning sessions in context B. (b) Switching the context disrupted the latent inhibition effect at the behavioral level. (c) Switching the context also eliminated differences in dopamine responses between the CS+ and pre-exposed CS+ (Nested ANOVA F(1,76)= 0.77, p=0.3838). Data represented as mean ± S.E.M., ns = not significant.