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. 2022 Dec 21;17:442. doi: 10.1186/s13023-022-02573-6

Table 2.

Grade of recommendation & criteria

Grade Descriptor Qualifying Evidence
A Strong recommendation Level I evidence or consistent findings from multiple studies of levels II, III, or IV
B Recommendation Levels II, III, or IV evidence and findings are generally consistent
C Option Levels II, III, or IV evidence, but findings are inconsistent
D Option Level V evidence: little or no systematic empirical evidence