FIG. 7.

Cysteine or serine proteases are required for processing of C. neoformans. (A) PBMC were stimulated with C. neoformans in the presence of various concentrations of the protease inhibitors leupeptin or antipain. (B) PBMC were also stimulated with SEB in the presence or absence of 100 μg of leupeptin or antipain per ml. ∗, P < 0.05 compared to stimulated PBMC in the absence of inhibitors. NS, not significant compared to stimulated PBMC in the absence of inhibitor. The experiment was repeated three times with similar results.