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. 2022 Nov 30;14(1):29–53. doi: 10.1039/d2sc04962g

Inorganic-based biomaterials for rapid hemostasis and wound healing.

Application field Material type Active inorganic component Biofunctions Ref.
Rapid hemostasis Natural mineral clays Zeolite, kaolin, montmorillonite Blood absorption, Ca2+ release, negative surface charge, mechanical strength enhancement, tissue adhesive 121 and 128
Silica-based mesoporous particles AgCaMSS, CSMS-S, Ga2O3-MBGs, Ta-MBGs, diatom silica Blood absorption, high surface aera and pore volume, Ca2+ release, negative surface charge 135, 138, 143 and 150
Inorganic–polymer composites Mesoporous single-crystal zeolite, NEM, HNTs, rectorite Blood absorption, concentrating coagulation factors, negative surface charge, tissue adhesive, physical barrier 40, 155, 159 and 165
Self-supporting inorganic-based biomaterials Graphene, GO, CNTs, ultralong HAP nanowires, hollow Al2O3 fibers Blood absorption, super hydrophilicity and hemophilicity, high surface aera, activation of platelets 36, 38, 150–153, 176 and 178
Wound healing Basic dressings CST5, FS, BP, t-ZnO, CaSiO3, SS Bioactive ion release, angiogenesis, PTT, CDT, skin defects regeneration 194, 201, 203 and 205
Therapeutic functional inorganic-based biomaterials TiO2-NTs, CaCuSi4O10, HMZS, hollow manganese silicate nanospheres Bioactive ion release, antibacterial activity, angiogenesis, skin appendage remolding, hair follicle regeneration 38, 179, 189, 212 and 215
Intelligently responsive inorganic-based biomaterials Ag3PO4/MoS2, LAPONITE® RDS, Ti3C2Tx, Fe3O4@SiO2, MoS2 nanosheet Antibacterial activity, angiogenesis, pH-responsive, PTT, PDT, controlled drug delivery, electrical stimulation 232–236
Rapid hemostasis and wound healing Dual functional inorganic-based biomaterials AgNPs, HNTs, CaCO3, ZnO mesocellular silica foam Blood absorption, negative surface charge, hemostasis drug release, antibacterial activity, reduce inflammation, promote re-epithelization and collagen deposition 53, 243, 245 and 246
Clot maintaining inorganic-based biomaterials AgNP-MSG, MSS@CaCO3T, CuS, Stober silica and iron oxide Blood absorption, negative surface charge, tissue adhesive, clot maintaining, antibacterial activity, degradability, bioactive ion release, biocompatibility 29, 248–250