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. 2022 Nov 16;13:1014638. doi: 10.3389/fimmu.2022.1014638

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Copyright © 2022 Zhang, Zhang, Zhao, Wang, Li, Wang, Zhang and Hu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immune characteristics of three subtypes. (A) Heatmap of immune cell fraction among three subtypes in TCGA BLCA cohort. (B) Boxplot of immune cell fraction among three subtypes in TCGA BLCA cohort. (C) Immune checkpoint of three subtypes in Meta cohort. (D) Immunophenogram for the visualization of the parameters determining immunogenicity. Boxplot showed the immune score of three subtypes in TCGA BLCA cohort (MHC, major histocompatibility complex-related molecules; EC, effector cells; SC, suppressor cells; CP, checkpoints or immunomodulators; AZ, averaged z-score; IPS, immunophenoscore). *P < 0.05, **P < 0.01, ***P < 0.001.